Surface charge critically affects tumor penetration and therapeutic efﬁcacy of cancer nanomedicines /Hong-Xia Wang a , e , 1 , Zu-Qi Zuo a , 1 , Jin-Zhi Du a , Yu-Cai Wang a ,∗∗ , Rong Sun b , Zhi-Ting Cao b , Xiao-Dong Ye b , Ji-Long Wang a , Kam W. Leong e ,∗∗ , Jun Wang a , b , c , - Wang,Hong-Xia