Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo

In behavioral tests, R + COF increased the locomotor activity in rotarod test compared to L-dopa + COF. L-Dopa combinations decreased the immobility time in FST compared to rasagiline combinations; L-dopa + CAF provided a similar increase in locomotor activity compared to R + CAF. Combination of CAF...

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Tác giả chính:	Aboutabl, Mona E.
Đồng tác giả:	Salman, Asmaa M.
Định dạng:	BB
Ngôn ngữ:	en_US
Thông tin xuất bản:	2023
Chủ đề:	Parkinson's disease Paraquat Coffee Rasagiline Caffeine Neurochemical disturbances Motor impairments Behavior tests
Truy cập trực tuyến:	http://tailieuso.tlu.edu.vn/handle/DHTL/12388
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spelling	oai:localhost:DHTL-123882023-03-16T02:43:14Z Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo Aboutabl, Mona E. Salman, Asmaa M. Gamal el Din, Amina A. Parkinson's disease Paraquat Coffee Rasagiline Caffeine Neurochemical disturbances Motor impairments Behavior tests In behavioral tests, R + COF increased the locomotor activity in rotarod test compared to L-dopa + COF. L-Dopa combinations decreased the immobility time in FST compared to rasagiline combinations; L-dopa + CAF provided a similar increase in locomotor activity compared to R + CAF. Combination of CAF or COF with L-dopa or rasagiline resulted in a substantial improvement in brain neurotransmitter and antioxidant levels as they significantly increased dopamine and super oxide dismutase but significantly decreased nitric oxide levels as compared to L-dopa or rasagiline, respectively. Furthermore, they also exerted a protective effect against the neurodegenerative histopathological changes induced by PQ. https://link.springer.com/article/10.1186/s42269-021-00678-9 2023-03-16T02:43:14Z 2023-03-16T02:43:14Z 2021 BB 2522-8307 http://tailieuso.tlu.edu.vn/handle/DHTL/12388 en_US Bulletin of the National Research Centre, Volume 44 (2021), Article number: 219
institution	Trường Đại học Thủy Lợi
collection	DSpace
language	en_US
topic	Parkinson's disease Paraquat Coffee Rasagiline Caffeine Neurochemical disturbances Motor impairments Behavior tests
spellingShingle	Parkinson's disease Paraquat Coffee Rasagiline Caffeine Neurochemical disturbances Motor impairments Behavior tests Aboutabl, Mona E. Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo
description	In behavioral tests, R + COF increased the locomotor activity in rotarod test compared to L-dopa + COF. L-Dopa combinations decreased the immobility time in FST compared to rasagiline combinations; L-dopa + CAF provided a similar increase in locomotor activity compared to R + CAF. Combination of CAF or COF with L-dopa or rasagiline resulted in a substantial improvement in brain neurotransmitter and antioxidant levels as they significantly increased dopamine and super oxide dismutase but significantly decreased nitric oxide levels as compared to L-dopa or rasagiline, respectively. Furthermore, they also exerted a protective effect against the neurodegenerative histopathological changes induced by PQ.
author2	Salman, Asmaa M.
author_facet	Salman, Asmaa M. Aboutabl, Mona E.
format	BB
author	Aboutabl, Mona E.
author_sort	Aboutabl, Mona E.
title	Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo
title_short	Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo
title_full	Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo
title_fullStr	Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo
title_full_unstemmed	Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo
title_sort	simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo
publishDate	2023
url	http://tailieuso.tlu.edu.vn/handle/DHTL/12388
work_keys_str_mv	AT aboutablmonae simultaneousadministrationofcoffeeandrasagilineldopaprotectsagainstparaquatinducedneurochemicalandmotorbehaviorimpairmentsinvivo
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Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo

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