The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals
Số 148 E9 (12): Tr. 7-15
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| Định dạng: | Bài trích |
| Ngôn ngữ: | English |
| Thông tin xuất bản: |
Journal of Medical Research
2023
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| Chủ đề: | |
| Truy cập trực tuyến: | http://thuvienso.thanglong.edu.vn//handle/TLU/5637 |
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oai:localhost:TLU-56372023-02-08T09:04:18Z The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals Pham Thi Van Anh, Nguyen Van Dam acute toxicity subchronic toxicity experimental animals Số 148 E9 (12): Tr. 7-15 The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/ day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of livers and kidneys of rats. In conclusion, DA DAI TRANG HVD capsules did not produce the acute and subchronic toxicities in Swiss mice and Wistar rats. 2023-02-08T09:04:18Z 2023-02-08T09:04:18Z 2021 Article http://thuvienso.thanglong.edu.vn//handle/TLU/5637 en application/pdf Journal of Medical Research |
| institution |
Trường Đại học Thăng Long |
| collection |
DSpaceTLongU |
| language |
English |
| topic |
acute toxicity subchronic toxicity experimental animals |
| spellingShingle |
acute toxicity subchronic toxicity experimental animals Pham Thi Van Anh, Nguyen Van Dam The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals |
| description |
Số 148 E9 (12): Tr. 7-15 |
| format |
Article |
| author |
Pham Thi Van Anh, Nguyen Van Dam |
| author_facet |
Pham Thi Van Anh, Nguyen Van Dam |
| author_sort |
Pham Thi Van Anh, Nguyen Van Dam |
| title |
The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals |
| title_short |
The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals |
| title_full |
The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals |
| title_fullStr |
The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals |
| title_full_unstemmed |
The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals |
| title_sort |
study of acute and subchronic toxicities of da dai trang hvd capsules in experimental animals |
| publisher |
Journal of Medical Research |
| publishDate |
2023 |
| url |
http://thuvienso.thanglong.edu.vn//handle/TLU/5637 |
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AT phamthivananhnguyenvandam thestudyofacuteandsubchronictoxicitiesofdadaitranghvdcapsulesinexperimentalanimals AT phamthivananhnguyenvandam studyofacuteandsubchronictoxicitiesofdadaitranghvdcapsulesinexperimentalanimals |
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